Abstract

This study was conducted to determine the in-vitro antioxidant, anti-lipid peroxidation and antiglycation activities of Sorghumbicolor methanolic leaf sheath extract using standard procedures. Concentration of antioxidant compounds, β-carotene, lycopene, total flavonoids and total phenolics in the plant extract are 71.74 and 88.84 µg/100mL, 11.68 ± 0.05 and 20.45 ± 0.12 mg/g, respectively. Sorghum bicolor methanolic leaf sheath extract showed a considerable high antioxidant activity when compared to ascorbic acid by scavenging DPPH and showing reducing property in a dose dependent manner. It also possessed the ability to inhibit lipid peroxidation and proteinglycation. From the result obtained, Sorghum bicolor methanolic leaf sheath extract contains bioactive components which possess antioxidant, antiglycation and anti-lipid peroxidation activity, thus, can be utilized to delay the onset of diabetes and diabetic complications.